{"id":174,"date":"2022-02-11T23:21:36","date_gmt":"2022-02-11T23:21:36","guid":{"rendered":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/?page_id=174"},"modified":"2025-11-05T07:16:57","modified_gmt":"2025-11-05T07:16:57","slug":"our-science","status":"publish","type":"page","link":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/our-science\/","title":{"rendered":"Our Science"},"content":{"rendered":"\n<div class=\"wp-block-cover is-light\" style=\"min-height:654px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"2200\" height=\"1240\" class=\"wp-block-cover__image-background wp-image-3051\" alt=\"\" src=\"https:\/\/kodiak-sciences-edge.go-vip.net\/wp-content\/uploads\/2022\/08\/our-science2.jpg\" style=\"object-position:0% 100%\" data-object-fit=\"cover\" data-object-position=\"0% 100%\" srcset=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg 2200w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg?resize=300,169 300w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg?resize=768,433 768w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg?resize=1024,577 1024w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg?resize=1536,866 1536w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg?resize=2048,1154 2048w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2022\/08\/our-science2.jpg?resize=572,322 572w\" sizes=\"auto, (max-width: 2200px) 100vw, 2200px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<h2 class=\"wp-block-heading\">PUSHING THE BOUNDARIES<\/h2>\n\n\n\n<p>At Kodiak, we are working to develop disruptive technologies to prevent and treat the leading causes of blindness<\/p>\n<\/div><\/div>\n\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\">ABCD PLATFORM<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<p class=\"has-text-align-center\">Our Antibody Biopolymer Conjugate Drug (ABCD) Platform is at the heart of our portfolio of next generation retinal medicines <\/p>\n\n\n\n<div class=\"wp-block-columns oursciencecandidates is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full oursciencecandidates\"><img loading=\"lazy\" decoding=\"async\" width=\"294\" height=\"294\" src=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/TarcoCandidate-1.png\" alt=\"\" class=\"wp-image-3395\" srcset=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/TarcoCandidate-1.png 294w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/TarcoCandidate-1.png?resize=150,150 150w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full oursciencecandidates\"><img loading=\"lazy\" decoding=\"async\" width=\"294\" height=\"294\" src=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/KSI501Candidate-1.png\" alt=\"\" class=\"wp-image-3396\" srcset=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/KSI501Candidate-1.png 294w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/KSI501Candidate-1.png?resize=150,150 150w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full oursciencecandidates\"><img loading=\"lazy\" decoding=\"async\" width=\"294\" height=\"294\" src=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/TripletCandidate-1.png\" alt=\"\" class=\"wp-image-3397\" srcset=\"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/TripletCandidate-1.png 294w, https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-content\/uploads\/sites\/4\/2023\/07\/TripletCandidate-1.png?resize=150,150 150w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center grid-col-12\">A PRODUCT PLATFORM ENABLING MULTI-MECHANISM THERAPIES EMPOWERED FOR DURABILITY<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-text-align-center\">The ABCD Platform is purposefully designed for durability and powered to combine multiple modalities, such as proteins and other Active Pharmaceutical Ingredients (&#8220;API&#8221;) at a high drug-antibody ratio, in a single therapeutic<\/p>\n\n\n\n<p class=\"has-text-align-center\">Explore the unique components of the ABCD Platform<\/p>\n\n\n\n<div class=\"particles-animation-container\">\n    <div class=\"particles-animation\">\n        <div class=\"left-buttons\">\n            <button id=\"antibody-button\" onmouseover=\"handleHover(this)\" onclick=\"handleClickImgParticles(this)\">\n                ANTIBODY OR <br class=\"only-desktop\" \/> OTHER BIOLOGIC\n            <\/button>\n            <button id=\"biopolymer-button\" onmouseover=\"handleHover(this)\" onclick=\"handleClickImgParticles(this)\">\n                BIOPOLYMER\n            <\/button>\n        <\/div>\n        <div class=\"particles-images\">\n            <div class=\"on-display\">\n                <img decoding=\"async\" class=\"\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Antibody1.png\" alt=\"\" style=\"filter: grayscale(100%)\">\n            <\/div>\n            <div class=\"antibody-images\">\n                <img decoding=\"async\" class=\"antibody\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Antibody1.png\" alt=\"particle\">\n                <img decoding=\"async\" class=\"antibody-pointer\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Antibody2.png\" alt=\"antibody-pointer\">\n            <\/div>\n            <div class=\"biopolymer-images\">\n                <img decoding=\"async\" class=\"antibody\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Biopolymer1.png\" alt=\"particle\">\n                <img decoding=\"async\" class=\"biopolymer-pointer\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Biopolymer2.png\" alt=\"biopolymer-pointer\">\n            <\/div>\n            <div class=\"drug-images\">\n                <img decoding=\"async\" class=\"antibody\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Drug1.png\" alt=\"conjugate\">\n                <img decoding=\"async\" class=\"drug-pointer\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Drug2.png\" alt=\"drug-pointer\">\n            <\/div>\n            <div class=\"conjugate-images\">\n                <img decoding=\"async\" class=\"conjugate\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/CandidateFullcolor.png\" alt=\"conjugate\">\n                <img decoding=\"async\" class=\"conjugate-pointer\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/conjugate.png\" alt=\"conjugate-pointer\">\n                <img decoding=\"async\" class=\"conjugate-pointer-mobile\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Conjugate_Mobile.png\" alt=\"conjugate-pointer-mobile\">\n            <\/div>\n        <\/div>\n        <div class=\"right-buttons\">\n            <button id=\"drug-button\" onmouseover=\"handleHover(this)\" onclick=\"handleClickImgParticles(this)\">\n                DRUG\n            <\/button>\n            <button id=\"conjugate-button\" onmouseover=\"handleHover(this)\" onclick=\"handleClickImgParticles(this)\">\n                CONJUGATE\n            <\/button>\n        <\/div>\n    <\/div>\n    <div class=\"particles-details\">\n        <div class=\"antibody-details\">\n            <div id=\"antibody-details-hover\">\n                <p>Engineered to exhibit high binding affinity and specificity. It can be any protein therapeutic, such as a monospecific or bispecific antibody.<\/p>\n            <\/div>\n            <div id=\"antibody-details-active\">\n                <p>Engineered to exhibit high binding affinity and specificity. It can be any protein therapeutic, such as a monospecific or bispecific antibody.<\/p>\n                <p>Conjugated to the biopolymer via a stable, site-specific linkage.<\/p>\n            <\/div>\n        <\/div>\n        <div class=\"biopolymer-details\">\n            <div id=\"biopolymer-details-hover\">\n                <p>A bioinspired polymer that is engineered to make medicines last longer and extend their therapeutic benefit. It is also powered to combine multiple modalities.<\/p>\n            <\/div>\n            <div id=\"biopolymer-details-active\">\n                <p>A bioinspired polymer that is engineered to make medicines last longer and extend their therapeutic benefit. It is also powered to combine multiple modalities.<\/p>\n                <p>The biopolymer is optically clear and made of phosphorylcholine, the primary hydrophilic component of human cell membranes. It creates a water force field around the protein therapeutic without obstructing the binding sites, shielding it from non-specific interactions and providing greater on-target potency.<\/p>\n            <\/div>\n        <\/div>\n        <div class=\"drug-details\">\n            <div id=\"drug-details-hover\">\n                <p>Small molecules and other APIs, such as oligonucleotides and peptides, can be embedded in the biopolymer backbone at a high drug-antibody ratio (DAR) and released over time to achieve targeted, multi-specific and tailored modulation of biological pathways.<\/p>\n            <\/div>\n            <div id=\"drug-details-active\">\n                <p>Small molecules and other APIs, such as oligonucleotides and peptides, can be embedded in the biopolymer backbone at a high drug-antibody ratio (DAR) and released over time to achieve targeted, multi-specific and tailored modulation of biological pathways.<\/p>\n                <p>The unique combination of high DAR and tailored therapeutic benefit offers potential for broad application to multifactorial ophthalmic and systemic diseases.<\/p>\n            <\/div>\n        <\/div>\n        <div class=\"conjugate-details\">\n            <div id=\"conjugate-details-hover\">\n                <p>A single therapeutic purposefully designed for durability and powered to combine multiple modalities for complex ocular and systemic diseases.<\/p>\n            <\/div>\n            <div id=\"conjugate-details-active\">\n                <p>More than the sum of its parts<\/p>\n                <p>A single therapeutic purposefully designed for durability and powered to combine multiple modalities for complex ocular and systemic diseases.<\/p>\n                <p>Ursus, Kodiak\u2019s custom commercial scale manufacturing facility designed for complex antibody conjugate biotherapies, is successfully commissioned as a cGMP facility for Kodiak\u2019s ABCD medicines.<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n\n<p class=\"has-text-align-center\"><\/p>\n\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"science-durability\" id=\"durability-animation\">\n    <div class=\"animation-container\">\n        <!--<img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/banner-ico.webp\" class=\"logo-animation\">-->\n        <h2 class=\"wp-block-heading has-text-align-center grid-col-12 mt-4\">SCIENCE OF DURABILITY<\/h2>\n        <div class=\"divider\"><\/div>\n        <p style=\"font-size: 18px;\">\n            ABCD Platform-derived medicines such as tarcocimab and KSI-501 are built to last. This designed-in durability is supported by clinical data and is what we call our <i>science of durability<\/i>.\n            <br\/> Four key elements support our science of durability\n        <\/p>\n    <\/div>\n<\/div>\n<div id=\"body-animation\" class=\"body-animation-content\">\n    <div class=\"animation-container\">\n        <img decoding=\"async\" class=\"arrow\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/content\/arrow.png\" style=\"width: 100%\">\n        <div class=\"container-animation\">\n            <div class=\"element-container\">\n                <div class=\"circle-animation\" id=\"circle-animation1\" onmouseover=\"changeContent(1)\">\n                    <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/image1.webp\">\n                <\/div>\n                <div class=\"card-animation\" onmouseover=\"changeContent(1)\">\n                    <div class=\"card-animation-header\">Conjugate Design<\/div>\n                    <div class=\"card-animation-body\">\n                        The ABCD Platform leverages a proprietary, phosphorylcholine-based polymer to increase \n                        molecular size and extend ocular half-life\n                    <\/div>\n                <\/div>    \n            <\/div>\n            <div class=\"element-container\">\n                <div class=\"circle-animation\" id=\"circle-animation2\" onmouseover=\"changeContent(2)\">\n                    <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/image2.webp\">\n                <\/div>\n                <div class=\"card-animation\" onmouseover=\"changeContent(2)\">\n                    <div class=\"card-animation-header\">High <i>In-vitro<\/i> Potency<\/div>\n                    <div class=\"card-animation-body\">\n                        Tarcocimab demonstrates strong potency in <i>in-vitro<\/i> assays\n                    <\/div>\n                <\/div>    \n            <\/div>\n            <div class=\"element-container\">\n                <div class=\"circle-animation\" id=\"circle-animation3\" onmouseover=\"changeContent(3)\">\n                    <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/image3.webp\">\n                <\/div>\n                <div class=\"card-animation\" onmouseover=\"changeContent(3)\">\n                    <div class=\"card-animation-header\">Extended Ocular Half-Life in Animals<\/div>\n                    <div class=\"card-animation-body\">\n                        Tarcocimab demonstrates 3x longer ocular half-life in rabbit models compared to approved intravitreal biologics\n                    <\/div>\n                <\/div>    \n            <\/div>\n            <div class=\"element-container\">\n                <div class=\"circle-animation\" id=\"circle-animation4\" onmouseover=\"changeContent(4)\">\n                    <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/image4.webp\">\n                <\/div>\n                <div class=\"card-animation\" onmouseover=\"changeContent(4)\">\n                    <div class=\"card-animation-header\">Extended Ocular Half-Life in Humans<\/div>\n                    <div class=\"card-animation-body\">\n                        Tarcocimab demonstrates 3x longer human ocular half-life compared to approved intravitreal biologics\n                    <\/div>\n                <\/div>    \n            <\/div>\n        <\/div>\n        <div class=\"content-animation\" id=\"content-box\">         \n        <\/div>    \n    <\/div>\n<\/div>\n<div id=\"body-animation-mobile\" class=\"body-animation-content\">\n    <div id=\"container-menus\">\n        <div id=\"circle-1\" class=\"circle-animation-mobile\" style=\"visibility: hidden;\" onclick=\"prevSlider()\">\n            <img decoding=\"async\" src=\"\">\n        <\/div>\n        <div id=\"circle-2\" class=\"circle-animation-mobile principal\">\n            <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/image1.webp\">\n        <\/div>\n        <div id=\"circle-3\" class=\"circle-animation-mobile\" onclick=\"nextSlider()\">\n            <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/icons\/image2.webp\">\n        <\/div>\n    <\/div>\n    <div class=\"animation-container\" id=\"animation-container-mobile\">\n        <div id=\"slide-mobile-1\">\n            <div class=\"card-animation\">\n                <div class=\"card-animation-header\">Conjugate Design<\/div>\n                <div class=\"card-animation-body\">\n                    The ABCD Platform leverages a proprietary, phosphorylcholine-based polymer to increase \n                    molecular size and extend ocular half-life\n                <\/div>\n            <\/div>\n            <div class=\"content-animation\">\n                <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/content\/slide-mobile-1.png\" onclick=\"setImgModal(this.src, '#0e2647');openModal('modal-image')\" style=\"width: 50%\" class=\"logo-animation\">\n                <ul>\n                    <li>Ocular half-life of an intravitreal biologic increases proportionally with molecular size<\/li>\n                    <li>The ABCD Platform leverages a high molecular weight, phosphorylcholine-based biopolymer that enables an extended ocular residence time compared to today's intravitreal biologics<\/li>\n                <\/ul>\n            <\/div>    \n        <\/div>\n        <div id=\"slide-mobile-2\">\n            <div class=\"card-animation\">\n                <div class=\"card-animation-header\">High <i>In-vitro<\/i> Potency<\/div>\n                <div class=\"card-animation-body\">\n                    Tarcocimab demonstrates strong potency in <i>in-vitro<\/i> assays\n                <\/div>\n            <\/div>\n            <div class=\"content-animation\">\n                <div class=\"content-col\">\n                    <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/content\/slide-mobile-2.png\" style=\"width: 100%\" onclick=\"setImgModal(this.src, '#0e2647');openModal('modal-image')\" class=\"logo-animation\">\n                    <ul>\n                        <li>Tarcocimab unconjugated protein and conjugated protein demonstrate high binding affinity and potency in preclinical assays \u2013 similar as aflibercept<\/li>\n                        <li>The increased molecular size from conjugation to the biopolymer does not impact binding affinity or potency<\/li>\n                    <\/ul>\n                <\/div>\n            <\/div>    \n        <\/div>\n        <div id=\"slide-mobile-3\">\n            <div class=\"card-animation\">\n                <div class=\"card-animation-header\">Extended Ocular Half-Life in Animals<\/div>\n                <div class=\"card-animation-body\">\n                    Tarcocimab demonstrates 3x longer ocular half-life in rabbit models compared to approved intravitreal biologics\n                <\/div>\n            <\/div>\n            <div class=\"content-animation\" style=\"flex-direction: column; justify-content: center;\">\n                <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/content\/slide-mobile-3.png\" onclick=\"setImgModal(this.src, '#0e2647');openModal('modal-image')\" style=\"width: 45%; margin: 0 auto; \" class=\"logo-animation\">\n                <div>\n                    <span>Tarcocimab demonstrates approximately <b>3x-4x longer ocular half-life<\/b> compared to aflibercept or faricimab in rabbit models<\/span>\n                    <ol>\n                        <li>Kodiak Data on File. Ocular half life was determined from a single 50 \u00b5L intravitreal injection of 0.725 mg of tarcocimab (conjugate) in rabbits.<\/li>\n                        <li>Gaudreault. et al. Retina 2007. 27: 1260-1266.<\/li>\n                        <li>Park S]. et al. IOVS 2016. 57: 2612-2617.<\/li>\n                        <li>Pharmacology \/ Toxicology BLA Review and Evaluation<\/li>\n                    <\/ol>\n                <\/div>\n            <\/div>\n        <\/div>\n        <div id=\"slide-mobile-4\">\n            <div class=\"card-animation\">\n                <div class=\"card-animation-header\">Extended Ocular Half-Life in Humans<\/div>\n                <div class=\"card-animation-body\">\n                    Tarcocimab demonstrates 3x longer human ocular half-life compared to approved intravitreal biologics\n                <\/div>\n            <\/div>\n            <div class=\"content-animation\">\n                <div class=\"content-col\">\n                    <span style=\"font-size: 13px;\">Tarcocimab has a mean ocular half-life in humans of <b>20 days, which is 3x longer<\/b> than faricimab's mean of 7.5 days, extending its therapeutic benefit in the eye<sup style=\"font-size: 12px\">1,2<\/sup><\/span>\n                    <div class=\"d-flex\" style=\"margin-top: 1rem;flex-direction: column; justify-content: center;\">\n                        <div style=\"width: 70%;max-width: 100%;position: relative; margin: 0 auto;\">\n                            <img decoding=\"async\" src=\"\/wp-content\/plugins\/durability-animation\/assets\/img\/content\/slide-mobile-4.png\" onclick=\"setImgModal(this.src, '#0e2647');openModal('modal-image')\" style=\"width: 100%;height: auto;display: block;\" class=\"logo-animation\">\n                        <\/div>\n                        <div style=\"display: flex;flex-direction: column;justify-content: space-between; font-size: 13px;padding-left: 12px;\">\n                            <ol style=\"font-size: 12px;\">\n                                <li>Ocular half-life was determined from aqueous humor concentration of tarcocimab over time in the Phase 1b study in wet AMD, DME and RVO. N=47 patients, all received an intravitreal injection of 5 mg tarcocimab clinical formulation on day 1.<\/li>\n                                <li>VABYSMO<sup>TM<\/sup> (faricimab solution for injection) Prescribing Information. South San Francisco, USA: Genentech, Inc. PK and ER of faricimab, Report # 1105763<\/li>\n                            <\/ol>\n                        <\/div>\n                    <\/div>\n                    <div class=\"conjugate-drug-box\" style=\"font-size: 11px;color: #276fa2;border-radius: 10px;\">\n                        <strong>How does extended ocular half-life in human translate into clinical durability?\n                        <\/strong>\n                        <p class=\"mt-4\" style=\"margin-bottom: 0;\">Tarcocimab demonstrated 5 to 6-month predominant durability in pivotal trials across all high-prevelence retinal vascular diseases<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n<!-- <div class=\"carousel-controls\" style=\"display: none;\">\n    <button id=\"prev\" onclick=\"prevSlider()\">\n        <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" fill=\"currentColor\" class=\"bi bi-arrow-left\" viewBox=\"0 0 16 16\">\n            <path fill-rule=\"evenodd\" d=\"M15 8a.5.5 0 0 0-.5-.5H2.707l3.147-3.146a.5.5 0 1 0-.708-.708l-4 4a.5.5 0 0 0 0 .708l4 4a.5.5 0 0 0 .708-.708L2.707 8.5H14.5A.5.5 0 0 0 15 8\"\/>\n        <\/svg>\n    <\/button>\n    <button id=\"next\" onclick=\"nextSlider()\">\n        <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" fill=\"currentColor\" class=\"bi bi-arrow-right\" viewBox=\"0 0 16 16\">\n            <path fill-rule=\"evenodd\" d=\"M1 8a.5.5 0 0 1 .5-.5h11.793l-3.147-3.146a.5.5 0 0 1 .708-.708l4 4a.5.5 0 0 1 0 .708l-4 4a.5.5 0 0 1-.708-.708L13.293 8.5H1.5A.5.5 0 0 1 1 8\"\/>\n        <\/svg>\n    <\/button>\n<\/div> -->\n\n\n\n\n<\/div>\n<\/div>\n\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\"><strong>SEE THE ABCD PLATFORM IN ACTION<\/strong><\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-text-align-center\">The ABCD Platform is inspired by nature and designed with water in mind. Travel through the eye to see how ABCD medicines are engineered for increased durability and efficacy<\/p>\n\n\n\n<div class=\"abc-platform\">\n    <div class=\"abc-platform-animation\">\n        <div class=\"images-container\">\n            <!--<div class=\"images-description\">\n                ABC Platform in action in the retina\n            <\/div>-->\n            <div class=\"images\">\n                <img decoding=\"async\" id=\"img-0\" class=\"on-display\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_0.png\">\n                <img decoding=\"async\" id=\"img-1\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_1.png\">\n                <img decoding=\"async\" id=\"img-2\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_2.png\">\n                <img decoding=\"async\" id=\"img-3\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_3.png\">\n                <img decoding=\"async\" id=\"img-4\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_4_2.png\">\n            <\/div>\n            <div class=\"images mobile-images\">\n                <img decoding=\"async\" id=\"mobile-img-0\" class=\"on-display\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_0.png\">\n                <img decoding=\"async\" id=\"mobile-img-1\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_1Mobile.png\">\n                <img decoding=\"async\" id=\"mobile-img-2\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_2Mobile.png\">\n                <img decoding=\"async\" id=\"mobile-img-3\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_3Mobile.png\">\n                <img decoding=\"async\" id=\"mobile-img-4\" src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/ABC_PLATFORM_IN_ACTION_4Mobile.png\">\n            <\/div>\n        <\/div>\n        <div class=\"details\">\n            <div id=\"details-1\">\n                <img decoding=\"async\"\n                        onmouseover=\"handleHoverABC(this)\"\n                        onmouseleave=\"handleLeaveABC(this)\"\n                        src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Square1.png\" alt=\"square\">\n                <div class=\"explanation\"\n                    onmouseover=\"handleHoverABC(this)\"\n                    onmouseleave=\"handleLeaveABC(this)\"\n                >\n                    <p>\n                        The ABCD Platform uses a <strong>bio-inspired polymer<\/strong> to orchestrate water around the antibody without obstructing the binding sites, preventing non-specific interactions\n                    <\/p>\n                <\/div>\n            <\/div>\n            <div id=\"details-2\">\n                <img decoding=\"async\"\n                        onmouseover=\"handleHoverABC(this)\"\n                        onmouseleave=\"handleLeaveABC(this)\"\n                        src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Square2.png\" alt=\"square\">\n                <div class=\"explanation\"\n                    onmouseover=\"handleHoverABC(this)\"\n                    onmouseleave=\"handleLeaveABC(this)\"\n                >\n                    <p>\n                        The ABCD molecule <strong>can slip through crowded or tight areas<\/strong> like retina tissue, that would otherwise impede it\n                    <\/p>\n                <\/div>\n            <\/div>\n            <div id=\"details-3\">\n                <img decoding=\"async\"\n                        onmouseover=\"handleHoverABC(this)\"\n                        onmouseleave=\"handleLeaveABC(this)\"\n                        src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Square3.png\" alt=\"square\">\n                <div class=\"explanation\"\n                    onmouseover=\"handleHoverABC(this)\"\n                    onmouseleave=\"handleLeaveABC(this)\"\n                >\n                    <p>\n                        The high lubricity of the ABCD molecule allows it to have ultra low friction, enabling it to <strong>penetrate tissues<\/strong>\n                    <\/p>\n                <\/div>\n            <\/div>\n            <div id=\"details-4\">\n                <img decoding=\"async\"\n                        onmouseover=\"handleHoverABC(this)\"\n                        onmouseleave=\"handleLeaveABC(this)\"\n                        src=\"\/wp-content\/plugins\/custom-particles\/assets\/img\/Square4.png\" alt=\"square\">\n                <div class=\"explanation\"\n                    onmouseover=\"handleHoverABC(this)\"\n                    onmouseleave=\"handleLeaveABC(this)\"            \n                >\n                    <p>\n                        Water influences antibody potency, enabling the ABCD molecule to bind to its target with <strong>high affinity and specificity<\/strong>\n                    <\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center oursciencebutton\"><a href=\"https:\/\/kodiak.com\/abc\/\" target=\"_blank\" rel=\"noreferrer noopener\">Follow the water: launch the ABCD digital experience <strong>\u2192<\/strong><\/a><\/p>\n\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":19,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-174","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/pages\/174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/comments?post=174"}],"version-history":[{"count":29,"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/pages\/174\/revisions"}],"predecessor-version":[{"id":4355,"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/pages\/174\/revisions\/4355"}],"wp:attachment":[{"href":"https:\/\/kodiak-sciences-develop.go-vip.net\/dotcom\/wp-json\/wp\/v2\/media?parent=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}